Motif ID: TFAP2{A,C}.p2

Z-value: 2.528


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Cchr20_+_54637714-0.145.9e-01Click!
TFAP2Achr6_-_10527772-0.116.9e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_72218661 7.061 MXRA7
matrix-remodelling associated 7
chr3_-_187025501 6.416 NM_001007225
NM_006548
 IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr17_-_72218535 5.021 NM_001008528
NM_001008529
NM_198530
 MXRA7


matrix-remodelling associated 7


chr19_-_18578467 4.672 CRLF1
cytokine receptor-like factor 1
chr19_-_18578631 4.557 NM_004750
 CRLF1
cytokine receptor-like factor 1
chr9_+_136673464 4.504 NM_000093
 COL5A1
collagen, type V, alpha 1
chr3_-_187025438 4.407 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr2_+_36436873 4.160 NM_016441
 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr11_-_65396775 4.070 NM_016938
 EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr19_-_18578577 4.044 CRLF1
cytokine receptor-like factor 1
chr15_-_46724360 3.846 FBN1
fibrillin 1
chr1_-_85703198 3.784 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_-_224612177 3.715 NM_001136528
NM_006216
 SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr3_-_151171190 3.618 NM_002628
NM_053024
 PFN2

profilin 2

chr4_-_158111995 3.482 NM_016205
 PDGFC
platelet derived growth factor C
chr2_+_235525355 3.452 NM_014521
 SH3BP4
SH3-domain binding protein 4
chr7_-_45927263 3.447 NM_000598
NM_001013398
 IGFBP3

insulin-like growth factor binding protein 3

chr3_-_126257425 3.399 NM_020733
 HEG1
HEG homolog 1 (zebrafish)
chr10_+_104394185 3.353 NM_030912
 TRIM8
tripartite motif containing 8
chr3_-_151171576 3.347 PFN2
profilin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
1.41 9.21e-04 GO:0030036 actin cytoskeleton organization
1.37 1.11e-03 GO:0030029 actin filament-based process
1.26 3.25e-03 GO:0000278 mitotic cell cycle
1.26 2.33e-02 GO:0007010 cytoskeleton organization
1.19 2.25e-02 GO:0022008 neurogenesis
1.18 1.30e-02 GO:0007049 cell cycle
1.17 7.97e-05 GO:0006996 organelle organization
1.16 1.37e-02 GO:0051641 cellular localization
1.14 2.98e-02 GO:0007399 nervous system development
1.12 1.59e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.11 2.84e-04 GO:0071840 cellular component organization or biogenesis
1.11 3.89e-03 GO:0071842 cellular component organization at cellular level
1.10 1.45e-05 GO:0044260 cellular macromolecule metabolic process
1.10 6.57e-04 GO:0016043 cellular component organization
1.10 1.20e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.07 1.22e-03 GO:0044237 cellular metabolic process
1.07 1.23e-02 GO:0043170 macromolecule metabolic process
1.04 7.40e-07 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
1.14 1.46e-02 GO:0005856 cytoskeleton
1.12 8.69e-04 GO:0005829 cytosol
1.12 1.62e-03 GO:0044428 nuclear part
1.11 2.27e-04 GO:0043234 protein complex
1.11 1.17e-02 GO:0070013 intracellular organelle lumen
1.11 2.48e-02 GO:0031981 nuclear lumen
1.10 5.32e-04 GO:0032991 macromolecular complex
1.10 3.89e-02 GO:0031974 membrane-enclosed lumen
1.09 2.23e-08 GO:0044444 cytoplasmic part
1.09 3.30e-08 GO:0044422 organelle part
1.09 5.63e-08 GO:0044446 intracellular organelle part
1.09 2.36e-02 GO:0043228 non-membrane-bounded organelle
1.09 2.36e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.08 1.06e-12 GO:0005737 cytoplasm
1.07 3.09e-12 GO:0043226 organelle
1.07 3.18e-12 GO:0043229 intracellular organelle
1.07 1.12e-09 GO:0043227 membrane-bounded organelle
1.07 1.48e-09 GO:0043231 intracellular membrane-bounded organelle
1.07 4.40e-03 GO:0005634 nucleus
1.06 5.60e-16 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.15 1.57e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.15 1.75e-04 GO:0017076 purine nucleotide binding
1.15 1.89e-04 GO:0032553 ribonucleotide binding
1.15 1.89e-04 GO:0032555 purine ribonucleotide binding
1.15 3.26e-03 GO:0030554 adenyl nucleotide binding
1.14 1.79e-05 GO:0000166 nucleotide binding
1.14 4.60e-03 GO:0032559 adenyl ribonucleotide binding
1.14 5.49e-03 GO:0005524 ATP binding
1.08 1.38e-10 GO:0005515 protein binding
1.03 2.46e-02 GO:0005488 binding